The 62-year-old actress is enjoying a career resurgence decades after the end of her hit show, Cheers, but her comeback didn’t come easy and she hopes that inspires her fans and Twitter followers.
“Never give up.....that's me talking to me as much as to you,” she tweeted on Friday.
The Emmy-winner admitted when doors are closed conceding to defeat is an attractive option. But the star vows not to quit.
“Boy sometimes it would be easier to just go live in a tent...until it rained," she added.
Kirstie catapulted back into the spotlight following her turn on Dancing With the Stars in 2011.
She's currently working on TV comedy Kirstie, about a 26-year-old who tries to connect with his birth mother after his adopted mother dies.
The actress recently admitted, however, there are some downsides to being back in the public eye.
In September, Kirstie was fuming after her attempt to run afternoon errands was thwarted by paparazzi. The star was livid that their presence meant she had to get dolled up for photos just to step out of her house.
"I hate the f**kin paparazzi !!! This son of a b**ch might as well just hang out my kitchen... He practically lives with us!!! Prius b**ch," she fumed on Twitter.
"I look look a*s!!!! GOD why do I have to dress up to go get a flippin manicure!!!!!! This tantrum could last a good 2 hours!!!!...!!!!!!!" she ranted.